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11 The well-known mechanism for p70S6K1 to promote survival is that p70S6K1 phosphorylates mouse double minute 2 (MDM2) leading to polyubiquitination and degradation of p53, and thus represses p53-dependent apoptosis

Homocysteine Homocysteine is recycled down by the methylation process, so elevated homocysteine is a red flag that methylation is impaired (and that risk of cardiovascular disease is elevated)