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Some patients also notice a mild fever or warmth, especially after B12 or high-dose B-complex formulations

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analyzed osteochondral tissue from 140 total knee replacement (TKR) Patients and 23 post-mortem (PM) specimens, identifying seven pathological features of BMLs: cysts, fibrosis, hypervascularity, cartilage islands, trabecular thickening, loss of tidemark integrity, and inflammatory cell infiltration [14]