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Recent clinical studies using 1 H-MRS showed that GSH levels in the brains of ALS patients were decreased compared to those of age-matched healthy volunteers [111], and the decreased GSH levels in the motor cortex and corticospinal tract were inversely correlated with the time after diagnosis [112]

Our analysis established that DNA hypomethylation in the CpG islands and shores may be one of the mechanisms in leading to GPX7 overexpression in LGG, agreeing with Peng et al

Atkuri, KR, Cowan, TM, Kwan, T, Ng, A, Herzenberg, LA, Herzenberg, LA, Enns, GM 2009, Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia, Proceedings of the National Academy of Sciences , vol

10.1038/s44318-024-00044-1 122 WangG.WangY.YangQ.XuC.ZhengY.WangL.et al (2022a)

Curr Opin Neurobiol