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High TLR-4 activity in epithelial cells results in the initiation of an exaggerated immune response with increased production of pro-inflammatory cytokines and destruction of the mucosal barrier 1

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Cervoni, J

Mixture as defined in claim 1 or mixture as defined in claim 8 or aroma mixture, formulation or composition as defined in claim 12 or 13, or use according to any one of claims 2 to 11 of a mixture as defined in claim 1 or a mixture as defined in claim 8, wherein the mixture or, respectively, the aroma mixture, formulation or composition further comprises (1) one or more further substances having physiological cooling action, wherein the further substance or one, more than one or all of the further substances (i) cause(s) a flavoring effect or (ii) do(es) not cause a flavoring effect, and/or (2) one or more aromas with no physiological cooling effect and/or (3) one or more substances having a trigeminal or mouthwatering effect with no physiological cooling effect and/or (4) (iii) one compound or (iv) two or more compounds which, independently or collectively in case (iv), additionally cause(s) a flavor-modulating effect and/or a trigeminal and/or mouthwatering stimulus

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