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Activation of the nuclear factor erythroid 2related factor 2 (Nrf2) pathway directly raises GSH levels, upregulates the transcription of genes involved in antioxidant defense, provides mitochondrial protection, facilitates the proliferation of detoxification enzymes and modulates neuroinflammation (Guerrero-Beltrn et al., 2012

doi: 10.1038/s41598-021-89394-y 27 StegerMTonelliFItoGDaviesPTrostMVetterMet al

Moreover, the 5-UR is essential for the interaction of V H and 5

The mechanistic insights from this study have implications beyond explaining toxicity

For living cells, control of metabolism and processes of cell development is of great importance