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A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria

For a broader primer on how researchers approach compound selection generally, see our complete peptide research guide

In a 2022 study of 175 overweight and obese patients (some with type 2 diabetes and some without), the study participants lost an average of 5.9% of their body weight after using Wegovy for three months and an average of 10.9% of their body weight after six months of treatment

In short, giving B12 to special groups needs a careful plan

If you are switching from a B12 pharmacy to a non-B12 pharmacy (or vice versa), the color change will be dramatic but entirely expected