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Hypercholesterolemia may exacerbate glaucoma through NOS-2-mediated oxidative damage to retinal ganglion cells [108] or vascular dysfunction impairing optic nerve perfusion [109, 110]

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Reconstituted solution must be further dilute before use (see accompanying literature)

Invasive procedures, such as central venous catheterization and lumbar puncture, should be avoided during the induction phase because of the high hemorrhagic risk during the initial phase of APL treatment.6,7 Management of hyperleukocytosis (white blood cell count 10 103/L) APL patients usually present with pancytopenia

Systematic investigations are, therefore, needed to unfold the roles of ginger, 6G and ZG on ferroptosis involved in CT side effect toxicity, as they are potential natural agents for the prevention of CT toxicity