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also soluble in polar aprotic solvents such as DMSO Storage: Store desiccated and protected from light

Current therapeutic strategies for OA-BMLs include non-weight-bearing protocols, pharmacological interventions such as diphosphonates (bone resorption inhibitors), prostaglandin I (PGI), and strontium ranelate (SrRan, a bone turnover inhibitor), as well as surgical approaches like bracing, subchondroplasty (bone substitute injection), high tibial osteotomy (HTO), unicompartmental knee arthroplasty (UKA), and total knee arthroplasty (TKA) [23]

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When B12 is deficient, COMT fails, adrenaline builds up, and the autonomic nervous system is thrown into a state of chaotic overdrive