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This may lead to subsequent physiological abnormalities including gut dysbiosis and systemic inflammation, eventually resulting in a pathological clotting system, chronic endothelialitis, vasoconstriction, and hypoxia, as found in similar conditions such as heat stroke (183)

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Conversely, in the high gene score group, Gemcitabine, PD0325901 (a MEK inhibitor), Ulixertinib (an ERK inhibitor), and Palbociclib (a CDK4/6 inhibitor) displayed greater sensitivity, indicating a potentially better therapeutic response to these agents ( Figure 10G )

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The next most common choice is 18, supported by 29% of Americans