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For example, engineering EVs to overexpress stimulator of interferon genes (STING) directly activates antigen-presenting cells within the tumor and the cyclic GMP-AMP synthase (cGAS)-STING pathway, initiating anti-tumor immune responses and inducing the formation of tertiary lymphoid structures with cytotoxic functions [186]

CCK-8 assay showed that anti-CCL11 inhibited cell proliferation of HUVECs stimulated with conditioned medium from hypoxia GSDMD-NC THP-1 cells, while CCL11 repaired weakened cell proliferation of HUVECs stimulated with conditioned medium from hypoxia GSDMD-KD THP-1 cells (Fig

For example, the utilization of iron chelators, such as deferoxamine, can effectively diminish the concentration of intracellular iron ions, thereby reducing iron-dependent ROS production (191)

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The strong abrogation of cellular ROS and lipid peroxide accumulation by cystamine is not due to its free radical-scavenging activity as this chemical is not a reducing agent (NH 2 CH 2 CH 2 SSCH 2 CH 2 NH 2 )