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The effects of Ginsenosides on PI3K/AKT signaling pathway

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In the TME, CPS1 expression varies across cancer types and is highly expressed in liver, pancreatic, kidney, colorectal, breast cancers, and non-small cell lung cancer (135, 146148)

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Notably, the voltage-dependent anion channel (VDAC) in the mitochondrial outer membrane, also known as the mitochondrial pore, acts as a gatekeeper for the entry and exit of mitochondrial metabolites and is a convergence point for its binding to various ligands and proteins to mediate various cell survival and cell death signals [47]