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An excess accumulation of cysteine results from the overexpression of cystathionine -synthase, as well as a reduction in homocysteine levels (Figure 2)

Furthermore, levels of oxidative phosphorylation (OXPHOS)-related proteins HSD17B10 and NDUFB8 prior to ICI therapy were found to follow a similar trend in predicting patient outcome

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In rare cases, it may be associated with a severe hepatotoxicity

For instance, overexpression of the transcription factor EB (TFEB) gene, a regulator of many crucial cellular processes including autophagy and lysosomal biogenesis, has been shown to modulate autophagy and lysosomal exocytosis with improved cellular clearance and delayed disease progression in Pompe disease [78,79]