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Research demonstrates that Dihexa binds to hepatocyte growth factor (HGF) with picomolar affinity and activates the c-Met receptor system, promoting formation of new synaptic connections in the hippocampus

doi: 10.1016/j.neuropharm.2012.03.016 177

Although Y54 does not directly interact with 2, it likely plays a structural role by stabilizing the positions of K52 and Y53

It works by mimicking growth hormone, releasing hormone (GHRH), which signals your brain to increase natural growth hormone production

Binding free energy analysis The binding free energy (G_bind) can be used to determine the stability and affinity of proteinligand complexes