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The most extensively studied stilbene is resveratrol (trans-3,5,4-trihydroxystilbene), which has attracted intense interest for its neuroprotective and longevity-enhancing properties

(2025c)

The hexosamine biosynthetic pathway and O-GlcNAcylation drive the expression of beta-catenin and cell proliferation

While some polyphenol-rich extracts, such as grape seed extract, have shown high tolerability in animal and short-term human studies, the safety of long-term, high-dose intake across a broad population spectrum remains to be confirmed (122, 123)

Vessby B, Uusitupa M, Hermansen K, Riccardi G, Rivellese AA, Tapsell LC, Nlsn C, Berglund L, Louheranta A, Rasmussen B