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The constructed NPs were surface-modified with HA to selectively target overexpressed cluster of differentiation 44 (CD44) receptors on cancer cells and catalytically generate highly efficient reactive oxygen species (ROS) via coordination chemistry

For example, a nanoemulsion-based adjuvant triggering Th17 responses combined to an RNA-based RIG-I agonist administered with the SARS-CoV-2 RBD by intranasal route was demonstrated to induce strong cross-reactive and long-lasting neutralizing IgA and Th1/Th17 driven vaccine responses in young and aged mice 78,79

However, these two classes differ fundamentally in their mechanisms of action, pharmacokinetics, target specificity, safety profiles, and translational pathways

Sankaranarayanan S, Jamshed M, Samuel MA

- The disease does not confer significative immunity and reinfections are frequent