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38 Base the injection frequency on symptoms, and not on biomarker assessment

The GRADE assessment showed moderate certainty of evidence for the increase in serum vitamin B12 levels and low certainty of evidence for homocysteine reduction, both across all studies and within RCT-only and observational-only subgroups

Vitamin B12 injections may be administered weekly or biweekly depending on baseline levels and symptoms

Possible Side Effects of Methylcobalamin Injection This injectable is thought to be particularly beneficial for addressing vitamin B12 insufficiency in the body

They should be administered by trained clinicians who screen properly first