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Some anecdotal and small observational reports support vasodilator therapies for Raynauds

In summary, while standard IV doses are usually safe, any severe symptoms should prompt immediate medical attention

Studies showed that p.N410I, p.L413V, and p.N410T, three gene mutations in exon 10, can increase the activity of GDH (about twice the normal value) [13, 14]

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Additionally, targeted therapies such as BRAF inhibitors (e.g., Vemurafenib) for patients with B-RAF mutations and CTLA-4 antibody ipilimumab provide new therapeutic possibilities alongside conventional chemotherapy (241)