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Category 3 are substances that were nominated but lack supporting information for the FDA to evaluate

NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict

During this phase, the dosage is reduced to 2-4 mg per week

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