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Detailed information about the developmental mechanisms or clinical aspects of CIPN has been reported in previous excellent reviews (Cavaletti and Marmiroli, 2010

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The N atoms and amino groups (NH) present on the pyrimidine and purine rings possess the capability to bind and release protons

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The majority of some tumor types such as CRC and prostate cancer, among others, remain mostly resistant to checkpoint inhibition therapy with the exception of those lesions with microsatellite instability