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If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy

Symptoms include difficulty breathing, facial or throat swelling, rapid heartbeat, hives, and a sudden drop in blood pressure

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VEGF Upregulation AHK-Cu has been associated with increased VEGF (vascular endothelial growth factor) production , a signaling protein that promotes blood vessel formation and is key for nutrient delivery to active hair follicles

Allergic Reactions In rare cases, some people may have a severe allergic reaction to ingredients in the B12 shot