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Modern surgical recovery protocols increasingly recognize that the quality and speed of healing depend not just on surgical technique, but also on providing the cellular environment and molecular signals necessary for optimal tissue repair

While large outcome trials were not specifically focused on acute MIRI, these studies in Table 1 provide clinical evidence of SGLT2 inhibitors influencing oxidative stress and related parameters in various patient populations

Delivering Se to cultured neurons via ionic selenite (SeO 2 ) increases GPX4 transcription and inhibits hemin- or homocysteine-induced ferroptosis [326]

Liposomal delivery systems address these challenges by isolating biomolecules from harsh external environments, improving their half-life, and facilitating targeted delivery to specific cells or tissues

Incorporating NAC into PMMA bone cement has significantly improved its bioactivity, as evidenced by enhanced osteogenic activity in rat BMSCs and MC3T3-E1 cells and favorable outcomes in bone regeneration in a rat femoral defect model (Tsukimura et al., 2009