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Prescription and administration: Once B12 deficiency is confirmed, GPs prescribe hydroxocobalamin injections according to standardised protocols: Standard loading regimen: 1mg intramuscularly three times weekly for two weeks Neurological involvement: 1mg intramuscularly on alternate days until no further improvement Maintenance therapy: 1mg every three months for life in pernicious anaemia or malabsorption conditions (or every two months if there was neurological involvement) Injections are typically administered by practice nurses at GP surgeries

IGF1 LR3s longer half-life makes it more suitable for systemic effects and sustained receptor start, while IGF-1 DESs shorter half-life may be advantageous for more localized or acute effects

Clinical trials show patients using tirzepatide lose significantly more weight than those on older GLP-1 medications alone