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In acute inflammation models, E2 appears to enhance TLR-mediated pro-inflammatory responses in human and murine macrophages while also promoting T2 and anti-inflammatory activity in allergic asthma and cutaneous wound healing (110, 115, 150157)

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Addressing cost and other issues related to access will be critical to realizing the full potential of the drug

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This dose corresponds to a M8891 minimal concentration at steady-state of 1500 ng/mL (3.9 M)

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