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We further mutated individual residues at the extracellular end of TM7 from E297 to I300 to proline and measured ghrelin-induced GHSR activation

Cell Tissue Res

[00346] Examples of genes for which a translatable molecule can be used to express the corresponding peptide or protein include: Duchenne muscular DMD, BMD dystrophy, 310200 (3) AIDS, delayed/rapid KIR3DL1, NKAT3, NKB1, AMBl l, KIR3DS1 progression to (3)

This helps reduce unnecessary agitation and supports product integrity during laboratory use

The synthetic mRNA construct of claim 1, wherein the mRNA construct comprises 5' cap m7GpppGm, a 5' UTR of A1G AT1G58420 (SEQ ID NO: 10), a Kozak sequence (SEQ ID NO: 121), a coding sequence encoding human coagulation factor IX (F9), one 3' UTR of human alpha globin (hAG) (SEQ ID NO: 81), and a poly(A) tail