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Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

We propose a cellular model of CVS in which an aberrant ion gradient begets mitochondrial dysfunction which begets further anomalous ion gradients, etc., forming a pathogenic vicious cycle leading to cellular hyperexcitability (Figure 1)

[DOI] [PubMed] [Google Scholar] 52.Lin K, Zheng W, Guo M, Zhou R, Zhang M, Liu T

Researchers found that, compared to placebo, L-carnitine L-tartrate supplementation was able to improve perceived recovery and soreness and lowered serum creatine kinase (a marker of muscle degeneration)

Oral chemotherapy in elderly women with metastatic breast cancer