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APOE-4 exhibits strong sex-dependent effects, with womenparticularly in mid-to-late older adulthoodshowing greater vulnerability to ADrelated neurodegeneration than men, including increased tau accumulation, more pronounced hippocampal and temporal cortical atrophy, and greater cognitive and neuropsychiatric burden (118, 121, 122)

Post-translational modification (PTM) of proteins involves the addition of moieties to target residues

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Moreover, CA, is transdiagnostically associated to psychiatry morbidity, and seems to play a role in the DNAm dysregulation of many of these pathways

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