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In addition, asiaticoside did not affect locomotor activity, suggesting that this compound does not have sedative effects [227]

Note on humans: These benefits are not established in humans the evidence is mostly older Russian and preclinical work with limited independent replication [13]

The FDA applied a four-part statutory test under 21 CFR 216.23(c): physical and chemical characterization, historical compounding use, evidence of effectiveness, and safety