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Polydatin was demonstrated to suppress the NLRP3 inflammasome, an important factor in the inflammatory response linked to DED

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A preliminary study showed that individuals with anxiety have significantly elevated plasma copper levels and very low zinc levels, and supplementation with zinc significantly improved anxiety symptoms (Russo, 2011)

In addition, inflammasome sensors that indirectly detect PAMPs or DAMPs include PYRIN and NLRP3