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Sakamoto J, Miura T, Shimamoto K, Horio Y (2004) Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain

WARNING: AGRANULOCYTOSIS AND NEUTROPENIA Ferriprox can cause agranulocytosis that can lead to serious infections and death

To evaluate this combination, we used the Zero Interaction Potency (ZIP) model, which accounts for independent drug effects and is particularly suited for combinations of agents with differing targets, such as DPI and vincristine (38)

Development of techniques of tumour tissue IHC with phosphoantibodies of c-MET and its downstream signal transducers molecules would enable the validation of inhibitor efficacy in the tumour tissue itself in future clinical studies of c-MET inhibitors