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For heart patients, it is important to consider the heart pumping (LVEF), and usually it should be given to patients with poor heart function under 30% LVEF, except few cases when it is really important

HHCY in HF could also be a consequence of kidney dysfunction associated with HF [207] since this organ is responsible for homocysteine clearance

These considerations are particularly important in research settings where compound consistency, stability assessment, and reproducibility are critical experimental factors.

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