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This breakdown is primarily caused by fungal enzymes, including pectic enzymes that include de-esterifying (pectin methylesterase) and depolymerizing (pectin lyase, polygalacturonase, and pectate lyase) enzymes [12]

Diabetes Care 45 , 27462748 (2022)

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Xiao J, Feng S, Wang X, Long K, Luo Y, Wang Y, et al

Examining the immunomodulatory impact of pre-existing proinflammatory conditions, such as stress, on subsequent infection, rats subjected to chronic psychosocial stress followed by systemic exposure of polyriboinosinic-polyribocytidilic acid (polyl:C) to mimic infection, experienced prolonged and increased pain sensitivity, or allodynia, and depressive-like behavior, as compared to control animals, as well as enhanced microglia activation (Chijiwa et al., 2015)