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Recent findings reveal that various molecules and pathways, including nuclear receptor coactivator 4, astrocyte-derived lactate, low-density lipoprotein receptor-related protein 1, and cGAS signaling, can influence cerebral IRI progression through unique lactylation mechanisms or by directly regulating overall lactylation levels [113,114,115,116]

Metabolites EGCG-2-cysteine and EGCG-2-cysteine were detected in urine following high-dose gavage of EGCG (233)

The emergence and selection of SIM are supported by studies of bacterial populations, in which reversible hypermutable phenotypes, sometimes in small-cell subpopulations, have the advantage of increasing population diversity without the drawback of continued accumulation of potentially dangerous mutations once cells adapt and exit stress 182,183

Lyko F Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases

Numerous therapies directed at specific targets have been suggested, some of which have yet to undergo clinical assessment