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B12 Overdose: In case of an overdose of B12, call your doctor immediately or seek emergency medical help

The endo-lysosomal pathway is a major bottleneck limiting the clinical efficacy of therapeutic agents, as nanoparticles are often sequestered and degraded following endocytosis, reducing bioavailability ( in vitro , as evidenced by the dispersion of gene cargo around the nucleus and a transient peak in the colocalization coefficient followed by a decrease, indicating successful endosomal escape

doi: 10.1002/adhm.202000948 52 CraftS.RamanR.ChowT

(25) Interestingly, the bioavailability of vitamin B12 in dietary supplements has been found to be around 50% higher than from food sources