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Future directions include nanoparticle systems bearing dual targeting (e.g., neutrophil receptor + adipose microenvironment ligand) and ROSresponsive release of antiNET agents timed to metabolic stress windows (e.g., postovulation, insulin surge)

In contrast, HepG2 cells with hamster S9-mix demonstrated 100% sensitivity for the chosen carcinogenic NAs

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Erythrocytes affect hemostasis and thrombosis by altering blood viscosity, blood flow dynamics, secreting RBC-derived microvesicles, interactions with platelets or endothelial cells, fibrinogen-induced RBC aggregation, activation of blood coagulation factors, direct modulation of thrombin and fibrin formation, or formation of polyhedral-like erythrocytes in thrombi [47,48,49]