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The released inflammatory mediators lead to the upregulation of adhesion molecules such as ICAM-1 on liver sinusoidal endothelial cells (LSECs) and hepatocytes as well as 2 integrins (CD11b/CD18) on neutrophils, which regulate the aggregation of immune cells through the production of mediators and the expression of adhesion molecules that assist neutrophil adhesion and transit within the sinusoids, adhesion to target cells and dependent oxidative stress, leading to hepatocyte death [19,20,21]

These findings of unknown reactions fill the previously unexplored metabolic network, complementing our understanding of the metabolic maps in cellular biochemistry

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DHA reductase activity was measured using DHA at 1 mM and 1 mM GSH

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