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Targeted LC-MS metabolomics analysis revealed enhanced Trp-to-kynurenine flux, elevated lactate, accumulation of citrate/isocitrate/aconitate, and a reduced -ketoglutarate/aconitate ratio (~ 0.6) restored by estradiol (~ 3.6)

From a translational perspective, integration of PWE or related polyphenol-rich formulations into preventive or early-intervention strategies, alone or in combination with standard pharmacotherapies, warrants investigation to define efficacy, safety, optimal dosing and patient subsets most likely to benefit

The micromanipulation measurements were arranged as previously described by Santinho et al

Wound healing A The exact science of how this works is not clear, but researchers theorize it may also be connected to the antioxidant and anti-inflammatory properties of thymoquinone