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H 2 S could inhibit the generation of reactive oxygen species (ROS) 70 and ameliorate the toxic effect of hypochlorous acid (HOCl) generated from myeloperioxidase (MPO) catalysis, thereby exerting anti-oxidant effects and protecting neuronal cells from cellular chlorinative damage 71
Although, in minor fractions, amino acids can also be utilized to generate butyrate via glutamate and lysine pathways
622 NMDA receptor antagonists Dextromethorphan: NMDA receptor antagonists may mitigate central sensitization and enhance descending inhibitory pathways involved in neuropathic pain