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The pivotal trial randomized 412 HIV-infected patients with abdominal fat accumulation to 2 mg of subcutaneous tesamorelin daily or placebo for 26 weeks, in a double-blind, placebo-controlled design

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Semaglutide Dosing Schedule With standard FDA-approved dosing, semaglutide starts at 0.25 mg once weekly for the first 4 weeks, then increases gradually every 4 weeks through a structured progression: 0.25 mg 0.5 mg 1.0 mg 1.7 mg 2.4 mg