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La L-carnitina viene riportata indietro nei mitocondri dove, con gruppi acilici, facilita l'utilizzo degli acidi grassi, tuttavia un eccesso di acetil-CoA pu bloccare questo processo

NAD deficiency has a direct correlation with chronic illness

This dose and time regiment was chosen as has been shown to be well-tolerated in mice while producing measurable biological effects on the mitochondria (Makowski et al., 2009