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Its inhibition reduces in vitro ferroptosis in mesangial cells induced by a medium high in glucose, as evidenced by a decrease in ACSL4 and an increase in GPX4 (66)

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Figure 2: Examples of Iron-Sulfur Clusters Image credit: Marvin, Chemaxon 3 The way the cluster is connected to the larger protein adds variation and fine-tuning

Liquid chromatography-mass spectrometry-based assays for acetyl-CoA (and other CoA derivatives) have been developed, validated, and applied in different contexts, with liquid chromatography-tandem mass spectrometry (LC-MS/MS), liquid chromatography-high resolution mass spectrometry (LC-HRMS), direct injection HRMS, and capillary electrophoresis-MS methods reported [3-13]