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In addition to inducing autophagy at lower concentrations, 4HNE can inhibit autophagic flux at higher concentrations ( Lipid peroxidation is implicated in various kinds of regulated cell death (Su et al., 2019)

Decano JL, Mattson PC, Aikawa M (2016) Macrophages in vascular inflammation: origins and functions

L., Ding, K., Liao, S

Glutathione has a fundamental, multifunctional role in modulating the redox status of cells, protecting them against oxidants and electrophiles, and detoxifying xenobiotics [14]