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For instance, depletion of mGSH results in Trx2 oxidation (Zhang et al., 2007), while hypercholesterolemic pigs with selective depletion of mGSH in heart mitochondria, exhibit decreased levels of the mitochondria-specific antioxidant enzymes such as SOD2, Trx2, and Prx3 (McCommis et al., 2011)

Update on therapies for sarcopenia: novel approaches for age-related muscle wasting and weakness

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If anything unusual develops, stop supplementation and consult your doctor

This distinction affects how the compound is absorbed, metabolized, and utilized in the body