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A few small studies have suggested that it may also have the potential of lightening skin tone due to its reported ability of preventing skin cells from producing melanin, the pigment responsible for darker complexions

In vitro, MM/MTXNPs diminished lipid accumulation in foam cells, while in vivo, they exhibited increased accumulation at plaque sites and more potent therapeutic effects in inhibiting plaque progression compared to free MTX or MTXNPs, thereby establishing HSP as a promising platform for effective and biocompatible atherosclerosis treatment [169]

No, and I want to be honest about that

It is notable that the beneficial effect of ARA 290 appears to be sustained for at least the 28-d follow-up period

Xiang, K, Wang, E, Mantyh, J, Rupprecht, G, Negrete, M, Sanati, G, Hsu, C, Randon, PM, Dohlman, AB, Kretzschmar, K, Bose, S, Giroux, N, Ding, S, Wang, L, Balcazar, JP, Huang, Q, Sundaramoorthy, P, Xi, R, McCall, S, Wang, Z, Jiang, C, Kang, Y, Kopetz, S , Crawford, G, Lipkin, SM, Wang, XF, Clevers, H, Hsu, D, Shen, X