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Rating: 4.8307 (6 reviews)

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& Howell, T

R.KrishnakumariS

Approval was based on the results of the KEYNOTE-177 trial (NCT02563002), the most recent in a series of studies focused on the effect of pembrolizumab on solid tumors that led to the 2017 landmark FDA approval of the immune checkpoint inhibitor as a tissue-agnostic treatment in patients with unresectable or metastatic solid tumors demonstrated to be MSI-H or dMMR who have progressed after first-line therapy [117119]

However, depletion of the cytoplasmic reader YTHDF1 increased CHIKV and decreased DENV viral titers, without affecting the levels of intracellular viral RNA or protein