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Glutamine is a non-essential amino acid with a high content in the normal human body that can provide a nitrogen source for the synthesis of purine and pyrimidine nucleotides, participate in the TCA cycle, and contribute to its carbon backbone, particularly when carbon is diverted to glycolytic pathways

Another important group of modifications is protein tags, which provide intracellular localization of proteins such as marking the proteins for transport to the proteasome, where they will be proteolyzed and hydrolyzed

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10.1002/path.1700350305 26

A simplified and schematic AsA biosynthetic pathway has been drawn, which reflects key intermediates involved therein