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The pool of reduced glutathione (GSH) is fueled by glutathione reductase (GR) activity, which catalyzes the reduction of glutathione disulfide (GSSG) to two molecules of GSH by electron transfer from NADPH

This synergistic action leads to the production of highly toxic RNOS, which directly targets and compromises mitochondrial function and energy metabolism

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2014;9:e108210

Productive trajectories (1 ms for each replica) were computed with an integration time step of 4 fs in the canonical ensemble (NVT)