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Early increases in the HIF-1 target phosphoglucomutase 1 (PGM1) in seal cells may regulate glucose metabolism during hypoxia, consistent with glycolytic repression via ZBTB7A transcriptional control [73, 74]

Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function

doi:10.1093/nar/gks891

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