(eds) Critical Care Toxicology
Use of vismodegib for the treatment of multiple basal cell carcinomas in a patient with xeroderma pigmentosum
In conclusion, the current study demonstrated, for the first time, that GSH depletion induces ferroptosis in RPE cells
Abbreviations ACE: Angiotensin I-converting enzyme ACSL4: AcylCoA synthetase longchain family member 4 AIF: Apoptosis-inducing factor Akt: Protein kinase B ALOX: Arachidonate lipoxygenase Apaf-1: Apoptotic protease activating factor-1 Bax: Bcl-2 associated X Bcl-2: B cell lymphoma 2 BDNF: Brain-derived neurotrophic factor BH4: Tetrahydrobiopterin CoQ10: Coenzyme Q10 COX: Cyclooxygenases CT: Chemotherapy CYP: Cyclophosphamide DHFR: Dihydrofolate reductase ERK: Extracellular signal-regulated kinase FSP1: Ferroptosis suppressor protein-1 FTH-1: Ferritin heavy chain-1 FTL-1: Ferritin light chain-1 GABA: Gamma-aminobutyric acid GPX-4: Glutathione peroxidase-4 GSK: Glycogen synthase kinase HO: Heme oxygenase IL: Interleukins iNOS: Inducible nitric oxide synthase IB: Kinase IKK JNK: Jun N-terminal kinase Keap1: Kelch-like ECH-associatedprotein 1 LncRNAs: LONG non-coding RNA LOX: Lipoxygenase MAPK: Mitogen-activated protein kinase mPTP: Mitochondrial permeability transition pore mTOR: Mammalian target of rapamycin NCOA4: Nuclear receptor coactivator 4 NF-B: Nuclear factor-kappa B NLRP: Nod-like receptor NOX: NADPH oxidase Nrf2: Nuclear factor-erythroid factor 2 PI3K: Phosphatidylinositol-3 kinase PLOOH: Phospholipid hydroxylperoxide PPAR-: Peroxisome proliferator-activated receptor- PUFA-CoA: Polyunsaturated fatty acid coenzyme-A PUFAs: Polyunsaturated fatty acids ROS/RNS: Reactive oxygen/reactive nitrogen species SIRS: Systemic inflammatory response syndrome SIRT1: Silent information regulator T1 SLC7A11: Light-chain subunit solute carrier family 7 member 11 SNP: Sodium nitroprusside STAT: Signal transducers and activators of transcription System Xc : Glutamate-cysteine transporter system TFR: Transferrin receptor TLR-4 : Toll-like receptor-4 TLR-4: Toll-like receptor-4 TNF: Tumour necrosis factor-alpha TRAIL: TNF-Related apoptosis-inducing ligand UPR: Unfolded protein response USP-14: Ubiquitin-specific protease-14 Wnt: Wingless-related integration site m: Mitochondrial membrane potential References Abdul-Hamid M, Salah M (2016) Intervention of ginger or propolis ameliorates methotrexate-induced ileum toxicity
After a recovery period of 3 days, AT-NC and AT-SIRT3OE mice were randomly separated into two groups, each 6 mice, and fed with an HFD (calorie 4.5 kcal/g, Trophic Animal Feed High-Tech Co., Nantong, Jiangsu, China) and regular chow diet (RD, calorie 2.35 kcal/g), respectively, for consecutive 13 weeks [35]
