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10.1038/onc.2008.188 87 RheeS

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Bioavailability issues in studying the health effects of plant polyphenolic compounds

At the periphery, the production of neopterin and nitric oxide during inflammation consumes tetrahydrobiopterin to the detriment of the hydroxylase enzymes that use this compound as a cofactor.[ref] Genetic variants can also significantly influence BH4 levels when the body is under stress