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It is also documented that the expression of CD44 in Mller glial cells increases following chronic ocular hypertension, which can impair autophagy in these cells (due to microglia-secreted osteopontin signaling) and lead to loss of RGCs [169]

Pan S, Hu B, Sun J, Yang Z, Yu W, He Z, et al

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Furthermore, the European Chemicals Agency (ECHA) has acknowledged the induction transient DNA strand breaks by GLY in both in vitro and in vivo testing (ECHA 2022)